Interferon gamma (IFN-g) is a key player regulating cell mediated immune responses. It was originally identified as an antiviral factor but also has crucial roles in activation of macrophages, stimulation of antigen presentation through class I and class II major histocompatibility complex (MHC) molecules, and regulation of T cell differentiation . IFN-g has been identified in many mammalian species but to date birds are the only non-mammal species whose IFN-g gene has been sequenced, using an expression cloning method .
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